ESTABLISHMENT OF STABLE, CELL-MEDIATED-IMMUNITY THAT MAKES SUSCEPTIBLE MICE RESISTANT TO LEISHMANIA-MAJOR

被引:474
作者
BRETSCHER, PA
WEI, GJ
MENON, JN
BIELEFELDTOHMANN, H
机构
[1] Department of Microbiology, University of Saskatchewan, Saskatoon
[2] University Department of Medicine, Queen Elizabeth II Medical Centre, Perth
关键词
D O I
10.1126/science.1636090
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cell-mediated, but not antibody-mediated, immune responses protect humans against certain pathogens that produce chronic diseases such as leishmaniasis. Effective vaccination against such pathogens must therefore produce an immunological "imprint" so that stable, cell-mediated immunity is induced in all individuals after natural infection. BALB/c mice "innately susceptible" to Leishmania major produce antibodies after substantial infection. In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge. This vaccination strategy may be applicable in diseases in which protection is dependent on cell-mediated immunity.
引用
收藏
页码:539 / 542
页数:4
相关论文
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