CHEMISTRY OF 1,3-DIOXEPINS .6. 1-SULFONYL-1A,2,6,6A-TETRAHYDRO-1H,4H-[1,3]-DIOXEPINO[5,6-B]AZIRINES - A NOVEL CLASS OF FUSED DIOXEPINS, POTENT HYPOGLYCEMIC AGENTS

被引：13

作者：

DUMIC, M ^{[1
]}

FILIC, D ^{[1
]}

VINKOVIC, M ^{[1
]}

JAMNICKY, B ^{[1
]}

KAMENAR, B ^{[1
]}

机构：

[1] UNIV ZAGREB,FAC SCI,GEN & INORGAN CHEM LAB,41000 ZAGREB,CROATIA

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 22期

关键词：

1,3]-DIOXEPINO[5,6-B]AZIRINE; N-SULFONYL-DIOXEPINOAZIRINE; HYPOGLYCEMIC ACTIVITY; X-RAY DIFFRACTION;

D O I：

10.1016/S0040-4039(00)73657-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new hypoglycemics, 1-sulfonyl-dioxepinoazirines 2, derived from a novel heterocyclic system, 1a,2,6,6a-tetrahydro-1H,4H-[1,3]-dioxepino[5,6-b]azirine, have been synthesized starting from trans-6-acetylamino-5-chloro-1,3-dioxepanes 7 via azirines 3. Their structure has been confirmed by the single crystal X-ray diffraction of 1-(4-acetylaminobenzenesulfonyl) derivative 2b.

引用

页码：3639 / 3642

页数：4

共 10 条

[1] DERMER OC, 1969, ETHLENIMINE OTHER AZ
[2] DUMIC M, 1992, ORG PREP PROCED INT, V24, P536
[3] DUMIC M, 1979, CROAT CHEM ACTA, V51, P259
[4] CONFORMATIONAL CHARACTERISTICS OF ANHYDROUS SULFAGUANIDINE - COMPUTER RETRIEVAL AND ANALYSIS OF N-SUBSTITUTED ARYLSULFONAMIDES
KALMAN, A
CZUGLER, M
ARGAY, G
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1981, 37 (APR): : 868 - 877
[5] LARSON ER, 1989, ANNU REP MED CHEM, V25, P205
[6] MOHRBACHER RJ, 1987, ANNU REP MED CHEM, V22, P213
[7] MORDES JP, 1985, JOSLINS DIABETES MEL, P110
[8] SOVAK M, 1983, Patent No. 4389526
[9] Steiner K E, 1987, Prog Med Chem, V24, P209, DOI 10.1016/S0079-6468(08)70423-5
[10] (+/-)-CIS-6-ACETYLAMINO-5-HYDROXY-1,3-DIOXEPANE
VINKOVIC, M
DUMIC, M
KAMENAR, B
[J]. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1992, 48 : 1352 - 1354

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