AN IMPROVED APPROXIMATION FOR CALCULATION OF CONFIDENCE-INTERVALS AFTER A SEQUENTIAL CLINICAL-TRIAL

被引：13

作者：

FACEY, KM

WHITEHEAD, J

机构：

[1] Department of Applied Statistics, University of Reading, Reading

来源：

STATISTICS IN MEDICINE | 1990年 / 9卷 / 11期

关键词：

D O I：

10.1002/sim.4780091107

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A method for the calculation of confidence intervals following a sequential clinical trial is proposed which is more accurate than methods based solely on continuous monitoring assumptions, but is not as computationally laborious as previous methods suggested for group sequential trials. The calculation takes account of the excess of the sample path over the boundary at the final inspection of the trial, which may be substantial after group sequential monitoring, and is ignored when continuous monitoring is assumed. Accuracy of such confidence intervals after a triangular test is investigated by simulation of coverage probabilities, individual confidence limit probabilities and p‐value curves. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：1277 / 1285

页数：9

共 16 条

[1]

Armitage P., Sequential Medical Trials, (1975)

[2]

Pocock S.J., Group sequential methods in the design and analysis of sequential clinical trials, Biometrika, 64, pp. 191-199, (1977)

[3]

O'Brien P.C., Fleming T.R., A multiple testing procedure for clinical trials, Biometrics, 35, pp. 549-556, (1979)

[4]

Whitehead J., The Design and Analysis of Sequential Clinical Trials, (1983)

[5]

Lan K.K.G., DeMets D.L., Discrete sequential boundaries for clinical trials, Biometrika, 70, pp. 659-663, (1983)

[6]

Whitehead J., On the bias of maximum likelihood estimation problems in clinical trials, Biometrika, 73, pp. 573-581, (1986)

[7]

Whitehead J., Marek P., A FORTRAN program for the design and analysis of sequential clinical trials, Computers and Biomedical Research, 18, pp. 176-185, (1985)

[8]

Whitehead J., Brunier H., Manual and computer package for Planning and Evaluation of Sequential Trials, PEST 2.0, (1989)

[9]

Rosner G.L., Tsiatis A.A., Exact confidence intervals following a sequential trial: a comparison of methods, Biometrika, 75, pp. 723-729, (1988)

[10]

Chang M.N., Confidence intervals for a normal mean following a group sequential test, Biometrics, 45, pp. 247-254, (1989)

← 1 2 →