GLYCEROL KINASE-DEFICIENCY INHIBITS GLYCEROL UTILIZATION IN PHOSPHOGLYCERIDE AND TRIACYLGLYCEROL BIOSYNTHESIS

被引：5

作者：

BARTLEY, JA ^{[1
]}

WARD, R ^{[1
]}

机构：

[1] UNIV IOWA, FAC PEDIAT, DIV MED GENET, IOWA CITY, IA 52242 USA

来源：

PEDIATRIC RESEARCH | 1985年 / 19卷 / 03期

关键词：

D O I：

10.1203/00006450-198503000-00012

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Glycerol 3-phosphate is an initial metabolite in the biosynthesis of phosphoglycerides and triacylglycerols. Both glycerol and glucose are precursors of glycerol 3-phosphate. Cultured skin fibroblasts from patients with glycerol kinase deficiency utilized glucose, but not glycerol in the biosynthesis of phosphoglycerides and triacylglycerols. Phosphoglyceride and triacylglycerol biosynthesis in glycerol kinase deficiency fibroblasts is not diminished by the inability to use glycerol as a precursor of glycerol 3-phosphate.

引用

页码：313 / 314

页数：2

共 11 条

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