HELIX ASSEMBLY IN SYNTHETIC POLYPEPTIDES .1. POLY(GAMMA-METHYL L-GLUTAMATE) FILM RETAINING CHOLESTERIC TWISTED STRUCTURE

被引:3
作者
SASAKI, S
DAIRAKU, M
机构
[1] Department of Polymer Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo
关键词
D O I
10.1021/ma00225a010
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A positionally disordered supermolecular structure in a synthetic polypeptide film was analyzed by X-ray diffraction. The helically twisted arrangement of the α-helices of poly(γ-methyl L-glutamate) (PMLG), formed in the lyotropic cholesteric liquid crystal, was retained in the film (I) prepared from the solution in 1,2-dichloroethane. In contrast to the highly crystalline film (II) prepared from the solution in chloroform, the X-ray diffraction pattern of I was broad but indicative of a particular intermolecular association. A stoichiometric complex with methanol (C), exhibiting sharp reflections, was formed for I but not for II. In the hexagonal unit cell of C, 12 or 13 helices were contained with a statistical disorder. The helices were delicately assembled so that the neighboring helices pointing in the same direction were separated by 13.2 Å while the antiparallel helices were separated by 11.1 Å. The methanol molecules were incorporated between the parallel helices. The disordered structure of I resulted from the reduction of the 13.2-Å distances to ca. 12#x00C5;. © 1990, American Chemical Society. All rights reserved.
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页码:4939 / 4943
页数:5
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