ROLE OF NEUTROPHILS IN THE INTESTINAL ALTERATIONS ASSOCIATED WITH THERMAL-INJURY

被引:7
作者
TROP, M [1 ]
SCHIFFRIN, EJ [1 ]
CARTER, EA [1 ]
机构
[1] MASSACHUSETTS GEN HOSP,SHRINERS BURN INST,DEPT PEDIAT,BOSTON,MA 02114
关键词
D O I
10.1016/0305-4179(90)90006-I
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
We have examined the role of neutrophils in the alterations observed in the intestines of rats subjected to 40 per cent surface area scald injury. Histologically, there was no evidence of neutrophilia in the intestinal tissue, and myeloperoxidase activity in mucosal scrapings was not elevated. The distribution of labelled human neutrophils injected into the burned rats showed no enhancement of uptake in the intestines, although there was increased uptake by the lung. The present data suggest that neutrophil migration may not play a role in the alterations in small intestinal function and morphology seen in burn trauma in the rat, but may be a factor in lung damage associated with thermal injury. © 1990.
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页码:343 / 346
页数:4
相关论文
共 22 条
[1]  
Alverdy, Aoys, Moss, Total parenteral nutrition promotes bacterial translocation from the gut, Surgery, 104, (1988)
[2]  
Carter, Udall, Kirkham, Et al., Thermal injury and gastrointestinal function: I Small intestinal nutrient absorption and DNA synthesis, J. Burn Care Rehabil, 7, (1986)
[3]  
Carter, Harmatz, Udall, Et al., Barrier defense function of the small intestine: effect of ethanol and acute burn trauma, Adv. Expl. Med. Biol., 216, (1987)
[4]  
Carter, Tompkins, Schiffrin, Et al., Cutaneous thermal injury alters macromolecular permeability of rat small intestine, Surgery, 107, (1990)
[5]  
Deitch, Granger, Berg, Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation, Surgery, 104, (1988)
[6]  
Demling, Lalonde, Liu, Et al., The lung inflammatory response and histological changes, Proc. Am. Burn Assoc., 21, (1989)
[7]  
Gonzalez-Crussi, Hsueh, Experimental model of ischemic bowel necrosis: the role of platelet-activating factor and endotoxin, Am. J. Pathol., 112, (1983)
[8]  
Granger, McCord, Parks, Et al., Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine, Gastroenterology, 90, (1988)
[9]  
Ismail, Morganroth, Todd, Et al., Prevention of pulmonary injury in isolated perfused rat lungs by activated human neutrophils preincubated with anti-Mol monoclonal antibody, Blood, 69, (1987)
[10]  
Linas, Shanley, Wittenburg, Et al., Neutrophils accentuate ischemia-reperfusion injury in isolated perfused rat kidneys, Am J Physiol, 255, (1988)