EXPERIENCE WITH AMOROLFINE IN THE TREATMENT OF DERMATOMYCOSES

被引：11

作者：

DELPALACIO, A ^{[1
]}

LOPEZGOMEZ, S ^{[1
]}

GARCIABRAVO, M ^{[1
]}

CUETARA, S ^{[1
]}

IGLESIASDIEZ, L ^{[1
]}

RODRIGUEZNORIEGA, A ^{[1
]}

机构：

[1] HOSP 12 OCTUBRE,DEPT DERMATOL,MADRID,SPAIN

来源：

DERMATOLOGY | 1992年 / 184卷

关键词：

AMOROLFINE; DERMATOMYCOSES; TOPICAL TREATMENT; BIFONAZOLE; MINIMUM INHIBITORY CONCENTRATION VALUES;

D O I：

10.1159/000247613

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In a double-blind randomized comparative study, 75 patients were treated with amorolfine cream 0.125, 0.25 or 0.5%. At the end of treatment clinical cure rates of 80, 76 and 84%, respectively, and mycological cures of 72, 64 and 76% were obtained. At 2 months posttherapy follow-up relapse rates were 0, 12 and 12%, respectively. There was no significant difference between the three groups in terms of clinical and mycological response, duration of treatment or tolerance. In a double-blind parallel study, 40 patients were treated topically with either 0.5% amorolfine cream or 1% bifonazole cream. The percentages of combined clinical and mycological cures were 83.3 and 78.95%, respectively. There was no significant difference in terms of tolerance and clinical and mycological cure rates. All treatments were applied once daily. Posttreatment MIC values did not indicate development of resistance to either amorolfine or bifonazole.

引用

页码：25 / 29

页数：5

共 18 条

[1]

ALLEVATO MAJ, 1988, UNPUB DATA FILE HOFF

[2]

BAUMGARTNER HP, 1984, GIT S, V6, P46

[3]

del Palacio A, 1991, J DERMATOLOGICAL TRE, V1, P299

[4] A CLINICAL DOUBLE-BLIND TRIAL COMPARING AMOROLFINE CREAM 0.5-PERCENT (RO-14-4767) WITH BIFONAZOLE CREAM 1-PERCENT IN THE TREATMENT OF DERMATOMYCOSES [J].