STATIC HEADSPACE GAS-CHROMATOGRAPHY OF RESIDUAL SOLVENTS IN PHARMACEUTICAL PRODUCTS

被引：27

作者：

RUSSO, MV

机构：

[1] Dipartimento di Chimica, Università 'La Sapienza' Roma, Roma, 00185

来源：

CHROMATOGRAPHIA | 1994年 / 39卷 / 11-12期

关键词：

GAS CHROMATOGRAPHY; HEADSPACE ANALYSIS; GONADOTROPINS; RESIDUAL SOLVENTS;

D O I：

10.1007/BF02274577

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A headspace, gas chromatographic method for determining residual solvents in pharmaceutical products such as the gonadotrophin powders, has been developed. The method allows the determination of residual solvents by transferring the samples directly into a vial containing 10 mL 2M sodium chloride; the analysis is carried out by sampling the headspace and separating by capillary gas chromatography using a programmed-temperature vaporizer (PTV) injector. The procedure described is simple, sensitive and reproducible. The lower limit of detection is 20 ppb for ethyl alcohol, 8 ppb for acetone and 0.5 ppb for diethyl ether.

引用

页码：645 / 648

页数：4

共 12 条

[1] AUTOMATIC HEADSPACE GAS-CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF TRICHLOROETHYLENE AND METABOLITES IN BLOOD AND URINE [J].