REGIONAL VARIATION IN TENSILE PROPERTIES AND BIOCHEMICAL-COMPOSITION OF THE HUMAN LUMBAR ANULUS FIBROSUS

被引：261

作者：

SKAGGS, DL

WEIDENBAUM, M

IATRIDIS, JC

RATCLIFFE, A

MOW, VC

机构：

[1] Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Columbia-Presbyterian Medical Center, New York, NY

来源：

SPINE | 1994年 / 19卷 / 12期

关键词：

ANULUS FIBROSUS; MECHANICAL PROPERTIES; COLLAGEN; PROTEOGLYCAN; DISC DEGENERATION;

D O I：

10.1097/00007632-199406000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Design. The structure-function relationship of anulus fibrosus of nondegenerate lumbar intervertebral discs was investigated. Objectives. The tensile properties and biochemical composition of single lamella specimens from human anulus fibrosus and their variations with anatomic region were determined. Summary of Background Data. Regional differences in composition and ultrastructure suggest differences in tensile properties. Methods. Single lamella specimens were isolated from the anulus, equilibrated in 0.15 mol/L NaCl and tested in uniaxial tension using a slow strain-rate protocol. Adjacent specimens were used to determine biochemical composition (including hydration, collagen, proteoglycan, and hydroxypyridinium crosslink density). Tensile properties, biochemical composition, and anatomic location were compared. Results. Significant radial and circumferential variations in tensile properties of anulus were detected, with the anterior being stiffer than the posterolateral regions, and the outer being stiffer than the inner regions. Conclusions. The regional differences in tensile properties may result predominantly from structural rather than compositional variations and may contribute to the clinical frequency of anulus failure in the posterolateral region.

引用

页码：1310 / 1319

页数：10

共 68 条

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