BETA-2-SYNTROPHIN - LOCALIZATION AT THE NEUROMUSCULAR-JUNCTION IN SKELETAL-MUSCLE

被引：125

作者：

PETERS, MF ^{[1
]}

KRAMARCY, NR ^{[1
]}

SEALOCK, R ^{[1
]}

FROEHNER, SC ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT PHYSIOL,CHAPEL HILL,NC 27599

来源：

NEUROREPORT | 1994年 / 5卷 / 13期

关键词：

DYSTROPHIN; UTROPHIN; 59; DAP; DUCHENNE MUSCULAR DYSTROPHY; ACETYLCHOLINE RECEPTOR CLUSTERING; MEMBRANE CYTOSKELETON;

D O I：

10.1097/00001756-199408150-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE syntrophins are a multigene family of proteins which bind C-terminal domains of dystrophin, utrophin and homologs thereof. We report here that antibodies specific for one isoform, beta 2-syntrophin, labeled only the neuromuscular junction (NMJ) in rat skeletal muscle. Anti-alpha 1-syntrophin antibodies gave strong labeling of the sarcolemma and NMJ in normal rat and mouse muscle, and similar but much weaker labeling in dystrophin-minus mdx muscle. beta 2-Syntrophin therefore appears to be specific to the NMJ in normal muscle, as is utrophin, and may be involved in acetylcholine receptor clustering. alpha 1-Syntrophin appears to be associated mainly with dystrophin, as expected, but a small portion must be associated with another protein, possibly homologs of the electric tissue 87K protein.

引用

页码：1577 / 1580

页数：4

共 25 条

[1] 2 FORMS OF MOUSE SYNTROPHIN, A 58-KD DYSTROPHIN-ASSOCIATED PROTEIN, DIFFER IN PRIMARY STRUCTURE AND TISSUE DISTRIBUTION [J].