CYCLIN-A LINKS C-MYC TO ADHESION-INDEPENDENT CELL-PROLIFERATION

被引：46

作者：

BARRETT, JF ^{[1
]}

LEWIS, BC ^{[1
]}

HOANG, AT ^{[1
]}

ALVAREZ, RJ ^{[1
]}

DANG, CV ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, JOHNS HOPKINS ONCOL CTR, BALTIMORE, MD 21205 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 27期

关键词：

D O I：

10.1074/jbc.270.27.15923

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive, In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

引用

页码：15923 / 15925

页数：3

共 17 条

[1] THE C-MYC PROTEIN INDUCES CELL-CYCLE PROGRESSION AND APOPTOSIS THROUGH DIMERIZATION WITH MAX
AMATI, B
LITTLEWOOD, TD
EVAN, GI
LAND, H
[J]. EMBO JOURNAL, 1993, 12 (13) : 5083 - 5087
[2] Myc and Max function as a nucleoprotein complex
Blackwood, Elizabeth M.
Kretzner, Leo
Eisenman, Robert N.
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1992, 2 (02) : 227 - 235
[3] DAKSIS JI, 1994, ONCOGENE, V9, P3635
[4] DEPINHO RA, 1991, ADV CANCER RES, V57, P1
[5] CELL-CYCLE CONTROL OF DNA-REPLICATION BY A HOMOLOG FROM HUMAN-CELLS OF THE P34CDC2 PROTEIN-KINASE
DURSO, G
MARRACCINO, RL
MARSHAK, DR
ROBERTS, JM
[J]. SCIENCE, 1990, 250 (4982) : 786 - 791
[6] CYCLIN-A IS REQUIRED FOR THE ONSET OF DNA-REPLICATION IN MAMMALIAN FIBROBLASTS
GIRARD, F
STRAUSFELD, U
FERNANDEZ, A
LAMB, NJC
[J]. CELL, 1991, 67 (06) : 1169 - 1179
[7] A LINK BETWEEN CYCLIN-A EXPRESSION AND ADHESION-DEPENDENT CELL-CYCLE PROGRESSION
GUADAGNO, TM
OHTSUBO, M
ROBERTS, JM
ASSOIAN, RK
[J]. SCIENCE, 1993, 262 (5139) : 1572 - 1575
[8] EFFECTS OF C-MYC EXPRESSION ON CELL-CYCLE PROGRESSION
HANSON, KD
SHICHIRI, M
FOLLANSBEE, MR
SEDIVY, JM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) : 5748 - 5755
[9] PARTICIPATION OF CYCLIN-A IN MYC-INDUCED APOPTOSIS
HOANG, AT
COHEN, KJ
BARRETT, JF
BERGSTROM, DA
DANG, CV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) : 6875 - 6879
[10] CYCLINS AND CANCER .2. CYCLIN-D AND CDK INHIBITORS COME OF AGE
HUNTER, T
PINES, J
[J]. CELL, 1994, 79 (04) : 573 - 582

← 1 2 →