SEPARATION OF DRUG-LOADED NANOPARTICLES FROM FREE DRUG BY GEL-FILTRATION

被引：28

作者：

BECK, P ^{[1
]}

SCHERER, D ^{[1
]}

KREUTER, J ^{[1
]}

机构：

[1] UNIV FRANKFURT,DEPT PHARMACEUT TECHNOL,W-6000 FRANKFURT,GERMANY

来源：

JOURNAL OF MICROENCAPSULATION | 1990年 / 7卷 / 04期

关键词：

D O I：

10.3109/02652049009040471

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A suitable method for separating free drug and other residual compounds from drug-loaded, colloidal polymeric particles was developed. The objective of this separation procedure was to purify particle suspensions on a preparative scale by a rapid, simple, and exact method without changing the properties of the particles. The gel filtration method described in this paper using a middle-pressure chromatographic system is able to meet all these requirements. The separation process could be optimized by using only water as an eluent in combination with Sephadex® G 50 medium. The purified particles appeared after 12-13 min in the eluate. Neither dispersity nor particle size or loading rate were influenced to a considerable extent. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：491 / 496

页数：6

共 14 条

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