LOW DEHYDROEPIANDROSTERONE CIRCULATING LEVELS IN PREMENOPAUSAL OBESE WOMEN WITH VERY HIGH BODY-MASS INDEX

被引：69

作者：

DEPERGOLA, G ^{[1
]}

GIAGULLI, VA ^{[1
]}

GARRUTI, G ^{[1
]}

COSPITE, MR ^{[1
]}

GIORGINO, F ^{[1
]}

CIGNARELLI, M ^{[1
]}

GIORGINO, R ^{[1
]}

机构：

[1] UNIV BARI,CATTEDRA ENDOCRINOL & MED COSTITUZ,MED CLIN 3,I-70124 BARI,ITALY

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1991年 / 40卷 / 02期

关键词：

D O I：

10.1016/0026-0495(91)90172-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dehydroepiandrosterone (DHEA) has an anti-obesity effect in rodents and reduces body fat in normal men. Therefore, the plasma levels of DHEA were evaluated in nine premenopausal healthy women and in 13 menstrually active nondiabetic obese women, including patients (n = 6) with body mass index (BMI) over 40. In the obese group, a significant inverse correlation between DHEA levels and BMI was found. These results suggest that patients with severe obesity are unable to increase the DHEA adrenal production rate in order to parallel the increase in the hormone metabolic clearance rate (due to enlargement of body fat mass per se). The deficiency of this mechanism might itself contribute to the progressive fat accumulation in severe obesity. © 1991.

引用

页码：187 / 190

页数：4

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