GLUCOSE-INDUCED INSULIN-RESPONSE IS REDUCED AND PROINSULIN RESPONSE INCREASED IN HEALTHY SIBLINGS OF TYPE-1 DIABETIC-PATIENTS

被引：21

作者：

LINDGREN, FA

HARTLING, SG

DAHLQUIST, GG

BINDER, C

EFENDIC, S

PERSSON, BE

机构：

[1] Department of Pediatrics, Karolinska Institute, Sachs' Children's Hospital, Stockholm

[2] Department of Endocrinology, Karolinska Institute, Karolinska Hospital, Stockholm

[3] Department of Pediatrics, Karolinska Institute, St. Göran's Children's Hospital, Stockholm

[4] Steno Memorial Hospital, Hagedorn Research Laboratory, Gentofte

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 07期

关键词：

PROINSULIN; GLUCOSE TOLERANCE TEST; HLA TYPES; SIBLINGS; TYPE-1; DIABETES;

D O I：

10.1111/j.1464-5491.1991.tb01670.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucose-stimulated insulin and proinsulin responses, and insulin sensitivity, were studied in 30 HLA identical, 38 HLA haplo-identical, and 25 HLA non-identical, healthy islet-cell-antibody negative siblings of Type 1 diabetic patients. The results were compared with 41 age- and sex-matched healthy subjects glucose diabetes in the family. The proinsulin-corrected insulin response to an intravenous glucose infusion test was significantly lower among siblings when insulin sensitivity was taken into account (1.65 (interquartile range 1.20-2.64) vs 2.18 (1.65-3.28) nmol mmol-1 min, p = 0.04). Proinsulin values were consistently higher among siblings than among control subjects (peak values 50.0 vs 38.0 pmol l-1 (p = 0.004)). When proinsulin release was corrected for individual insulin sensitivity this difference remained. The results suggest disturbed islet B-cell function, unrelated to HLA identity or the presence of circulating islet cell antibodies.

引用

页码：638 / 643

页数：6

共 23 条

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