STEREOSELECTIVE SYNTHESIS OF A TRANS-OCTAHYDROINDOLE DERIVATIVE, PRECURSOR OF TRANDOLAPRIL (RU-44 570), AN INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME

被引：30

作者：

BRION, F ^{[1
]}

MARIE, C ^{[1
]}

MACKIEWICZ, P ^{[1
]}

ROUL, JM ^{[1
]}

BUENDIA, J ^{[1
]}

机构：

[1] ROUSSEL UCLAF,102 ROUTE NOISY,F-93230 ROMAINVILLE,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)61225-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1. The optically active starting material used was obtained by an enzymatic hydrolysis.

引用

页码：4889 / 4892

页数：4

共 14 条

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