RECOMBINANT GABA(A) RECEPTOR FUNCTION AND ETHANOL

被引：89

作者：

SIGEL, E ^{[1
]}

BAUR, R ^{[1
]}

MALHERBE, P ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE & CO LTD,PHARMACEUT RES DEPT,CH-4051 BASEL,SWITZERLAND

来源：

FEBS LETTERS | 1993年 / 324卷 / 02期

关键词：

GAMMA-AMINOBUTYRATE RECEPTOR; XENOPUS OOCYTE; ION CHANNEL; ETHANOL; EXPRESSION;

D O I：

10.1016/0014-5793(93)81380-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Different combinations of cloned subunits of the rat brain GABA(A) receptor were expressed in Xenopus oocytes. Possible effects of ethanol on the expressed GABA-induced chloride current were determined. The consequence of replacing the gamma2S subunit by the alternatively spliced variant gamma2L was specifically tested on the responsiveness to ethanol. A significant stimulation of the GABA response was only observed at very high concentrations (> 60 mM) of ethanol. No differential response was observed between subunit combinations containing different gamma2 subunit splice variants.

引用

页码：140 / 142

页数：3

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