NON-LINEAR DISPOSITION OF THIOPENTONE FOLLOWING LONG-TERM INFUSION

被引：13

作者：

LECORRE, P ^{[1
]}

MALLEDANT, Y ^{[1
]}

TANGUY, M ^{[1
]}

LEVERGE, R ^{[1
]}

机构：

[1] CTR HOSP REG & UNIV RENNES,HOP PONTCHAILLOU,DEPT ANESTHESIOL & REANIMAT,RENNES,FRANCE

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1993年 / 18卷 / 03期

关键词：

THIOPENTONE; NON LINEAR; DISPOSITION; LONG-TERM INFUSION;

D O I：

10.1007/BF03188805

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of thiopentone administered at infusion rates ranging 45-11.5 mg.kg(-1) .h(-1) for 50-130 h was studied in 6 patients with neurologic evidence of severe cerebral damage. Arterial plasma concentrations of thiopentone were measured during and after discontinuation of the infusion. The postinfusion plasma concentrations were fitted to the one compartment Michaelis-Menten model. At the end of the infusion, the level of saturation of the enzymatic systems ranged 67.0-95.7%. Vm was on average 0.93 +/- 0.57 mg.l(-1) .h(-1). The mean plasma clearance was 2.0 +/- 1.4 ml.min(-1) .kg(-1). The apparent half-life of the terminal phase was 5.5 +/- 3.9 h.

引用

页码：255 / 259

页数：5

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