PULMONARY MACROPHAGE FUNCTION IN SYSTEMIC GADOLINIUM CHLORIDE-PRETREATED RATS

被引:22
作者
BANNENBERG, G
LUNDBORG, M
JOHANSSON, A
机构
[1] KAROLINSKA INST, INST ENVIRONM MED, DIV INHALAT TOXICOL, S-17177 STOCKHOLM, SWEDEN
[2] KAROLINSKA INST, INST ENVIRONM MED, DIV TOXICOL, S-17177 STOCKHOLM, SWEDEN
关键词
PULMONARY MACROPHAGE; ALVEOLAR MACROPHAGE; INTERSTITIAL MACROPHAGE; GADOLINIUM CHLORIDE;
D O I
10.1016/0378-4274(95)03342-I
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The potential use of systemic gadolinium chloride pretreatment of rats as a tool to inhibit pulmonary macrophage function was studied by measurement of its effect on phagocytosis and nitroblue tetrazolium reduction by alveolar and interstitial macrophages. Gadolinium chloride solution was administered through the tail vein 48 h before the animals were killed. At 10 mg/kg, a dose which is generally used to inhibit Kupffer cell function, no effect on pulmonary macrophages was observed. Neither did a higher dose, 20 mg/kg, affect pulmonary macrophage function. It is concluded that gadolinium chloride pretreatment does not affect alveolar and interstitial macrophages upon systemic administration at doses and time after administration that generally depress Kupffer cell functioning.
引用
收藏
页码:105 / 107
页数:3
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