COADMINISTRATION OF (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID AND ARACHIDONIC-ACID POTENTIATES SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPAL SLICES

被引：30

作者：

COLLINS, DR ^{[1
]}

DAVIES, SN ^{[1
]}

机构：

[1] UNIV ABERDEEN MARISCHAL COLL,DEPT BIOMED SCI,ABERDEEN AB9 1AS,SCOTLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 240卷 / 2-3期

关键词：

LONG-TERM POTENTIATION; ARACHIDONIC ACID; METABOTROPIC RECEPTOR;

D O I：

10.1016/0014-2999(93)90919-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Perfusion of the 1S,3R isomer of trans-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD, 50 muM), or arachidonic acid (10 muM), for 5 min produced only depression of the field excitatory postsynaptic potential recorded in the CA1 region of rat hippocampal slices from which the CA3 region had been removed. However, perfusion of t-ACPD and arachidonic acid in combination induced a rapid potentiation of the response which in 4/6 slices was maintained for at least 90 min.

引用

页码：325 / 326

页数：2

共 8 条

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