AMINO-ACIDS, SEROTONIN, AND 5-HYDROXYINDOLEACETIC ACID FOLLOWING FOOT SHOCK IN RATS

被引：14

作者：

MALYSZKO, J ^{[1
]}

URANO, T ^{[1
]}

TAKADA, Y ^{[1
]}

TAKADA, A ^{[1
]}

机构：

[1] HAMAMATSU UNIV,SCH MED,DEPT PHYSIOL,HAMAMATSU,SHIZUOKA 43131,JAPAN

来源：

BRAIN RESEARCH BULLETIN | 1995年 / 36卷 / 02期

关键词：

AMINO ACIDS; TRYPTOPHAN; SEROTONIN; 5-HYDROXYINDOLEACETIC ACID; FOOT SHOCK; BRAIN;

D O I：

10.1016/0361-9230(94)00178-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Concentrations of tryptophan, serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in brain and plasma, as well as plasma amino acid composition, were measured after 1-h foot shock. Stress induced a rise in both plasma and brain 5-HIAA, whereas 5-HT concentration was found to be increased only in plasma. A prominent rise in brain tryptophan was observed, whereas in plasma, foot shock caused a significant increase only in tryptophan level. Concentrations of other amino acids were found to be either decreased or unchanged. Ratio of tryptophan to the other long-chain neutral amino acids increased significantly following foot shock. It is possible that stress-related changes in 5-HT turnover are due to increased plasma tryptophan, in turn causing a rise in brain tryprophan, necessary to cope with enhanced 5-HT metabolism, reflected as a rise in 5-HIAA levels.

引用

页码：137 / 140

页数：4

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