ERYTHROPOIETIN INDUCES TYROSINE PHOSPHORYLATION OF THE BETA-CHAIN OF THE GM-CSF RECEPTOR

被引：50

作者：

HANAZONO, Y ^{[1
]}

SASAKI, K ^{[1
]}

NITTA, H ^{[1
]}

YAZAKI, Y ^{[1
]}

HIRAI, H ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 208卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (EPO) induce tyrosine phosphorylation of the GM-CSF receptor beta chain and the EPO receptor, respectively, although their receptors lack the tyrosine kinase activity. We have shown that EPO as well as GM-CSF induces tyrosine phosphorylation of the beta chain. Conversely, GM-CSF does not induce tyrosine phosphorylation of the EPO receptor. Tyrosine phosphorylation of the beta chain by stimulation with EPO is rapid and transient. EPO may trans-modulate a signaling pathway of GM-CSF by phosphorylating the beta chain of the GM-CSF receptor. (C) 1995 Academic Press, Inc.

引用

页码：1060 / 1066

页数：7

共 16 条

[1]

HANAZONO Y, 1993, BLOOD, V81, P3193

[2] C-FPS/FES PROTEIN-TYROSINE KINASE IS IMPLICATED IN A SIGNALING PATHWAY TRIGGERED BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND INTERLEUKIN-3 [J].

HANAZONO, Y ;

CHIBA, S ;

SASAKI, K ;

MANO, H ;

MIYAJIMA, A ;

ARAI, K ;

YAZAKI, Y ;

HIRAI, H .

EMBO JOURNAL, 1993, 12 (04) :1641-1646

[3] MOLECULAR-CLONING OF A 2ND SUBUNIT OF THE RECEPTOR FOR HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) - RECONSTITUTION OF A HIGH-AFFINITY GM-CSF RECEPTOR [J].

HAYASHIDA, K ;

KITAMURA, T ;

GORMAN, DM ;

ARAI, KI ;

YOKOTA, T ;

MIYAJIMA, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9655-9659

[4] CYTOKINE SIGNAL-TRANSDUCTION [J].

KISHIMOTO, T ;

TAGA, T ;

AKIRA, S .

CELL, 1994, 76 (02) :253-262

[5]

KOMATSU N, 1991, CANCER RES, V51, P341

[6]

MANO H, 1995, BLOOD, V85, P343

[7] INDUCTION OF TYROSINE PHOSPHORYLATION BY THE ERYTHROPOIETIN RECEPTOR CORRELATES WITH MITOGENESIS [J].

MIURA, O ;

DANDREA, A ;

KABAT, D ;

IHLE, JN .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (10) :4895-4902

[8]

MIYAJIMA A, 1993, BLOOD, V82, P1960

[9] LOCALIZED CYTOSOLIC DOMAINS OF THE ERYTHROPOIETIN RECEPTOR REGULATE GROWTH SIGNALING AND DOWN-MODULATE RESPONSIVENESS TO GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR [J].

QUELLE, DE ;

WOJCHOWSKI, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4801-4805

[10] JAK2 ASSOCIATES WITH THE BETA(C) CHAIN OF THE RECEPTOR FAR GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR, AND ITS ACTIVATION REQUIRES THE MEMBRANE-PROXIMAL REGION [J].

QUELLE, FW ;

SATO, N ;

WITTHUHN, BS ;

INHORN, RC ;

EDER, M ;

MIYAJIMA, A ;

GRIFFIN, JD ;

IHLE, JN .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4335-4341

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