MECHANISM OF CELL-DAMAGE BY ULTRASOUND IN COMBINATION WITH HEMATOPORPHYRIN

被引：274

作者：

UMEMURA, S ^{[1
]}

YUMITA, N ^{[1
]}

NISHIGAKI, R ^{[1
]}

UMEMURA, K ^{[1
]}

机构：

[1] TOHO UNIV,SCH PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 09期

关键词：

Active oxygen scavenger; Cell damage; Hematoporphyrin; Singlet oxygen; Ultrasound;

D O I：

10.1111/j.1349-7006.1990.tb02674.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanism of cell damage by ultrasound in combination with hematoporphyrin was studied. Mouse sarcoma 180 cell suspensions were exposed to ultrasound for up to 60 s in the presence and absence of hematoporphyrin, with and without active oxygen scavengers. The cell damage enhancement by hematoporphyrin was suppressed by adding histidine but not by mannitol. The enhancement was doubled in rate by substitution of deuterium oxide medium for normal water. Sonoluminescence was produced in a saline solution under similar acoustic conditions and observed to have spectral components that can excite hematoporphyrin molecules. These results suggest that cell damage enhancement is probably mediated via singlet oxygen generated by ultrasonically activated hematoporphyrin. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：962 / 966

页数：5

共 14 条

[1]

CHARLES JG, 1979, CANCER RES, V39, P146

[2] PHOTORADIATION THERAPY .2. CURE OF ANIMAL TUMORS WITH HEMATOPORPHYRIN AND LIGHT [J].

DOUGHERTY, TJ ;

GRINDEY, GB ;

FIEL, R ;

WEISHAUPT, KR ;

BOYLE, DG .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1975, 55 (01) :115-121

[3]

HAYATA H, 1982, CHEST, V81, P269

[4] FREE-RADICAL FORMATION AND CELL-LYSIS INDUCED BY ULTRASOUND IN THE PRESENCE OF DIFFERENT RARE-GASES [J].

KONDO, T ;

GAMSON, J ;

MITCHELL, JB ;

RIESZ, P .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 54 (06) :955-962

[5]

KREMKAU FW, 1979, J CLIN ULTRASOUND, V7, P287, DOI 10.1002/jcu.1870070410

[6]

LELE PP, 1982, PHYSICAL ASPECTS HYP, P393

[7] CHEMISTRY OF SINGLET OXYGEN .42. EFFECT OF SOLVENT, SOLVENT ISOTOPIC-SUBSTITUTION, AND TEMPERATURE ON THE LIFETIME OF SINGLET MOLECULAR-OXYGEN (1-DELTA-G) [J].

OGILBY, PR ;

FOOTE, CS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (11) :3423-3430

[8]

ROGERS MAJ, 1983, J AM CHEM SOC, V105, P6201

[9]

Ter Haar GR, 1988, ULTRASOUND ITS CHEM, P305

[10]

UMEMURA S, 1989, 1989 P IEEE ULTR S N, P955

← 1 2 →