A CYCLIC AMP-ACTIVATED K+ CHANNEL IN DROSOPHILA LARVAL MUSCLE IS PERSISTENTLY ACTIVATED IN DUNCE

被引：65

作者：

DELGADO, R ^{[1
]}

HIDALGO, P ^{[1
]}

DIAZ, F ^{[1
]}

LATORRE, R ^{[1
]}

LABARCA, P ^{[1
]}

机构：

[1] UNIV CHILE,FAC CIENCIAS,DEPT BIOL,SANTIAGO,CHILE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 02期

关键词：

D O I：

10.1073/pnas.88.2.557

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.

引用

页码：557 / 560

页数：4

共 28 条

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