PHOSPHORYLATION DEPHOSPHORYLATION OF THE BETA-ADRENERGIC-RECEPTOR REGULATES ITS FUNCTIONAL COUPLING TO ADENYLATE-CYCLASE AND SUBCELLULAR-DISTRIBUTION

被引:219
作者
SIBLEY, DR [1 ]
STRASSER, RH [1 ]
BENOVIC, JL [1 ]
DANIEL, K [1 ]
LEFKOWITZ, RJ [1 ]
机构
[1] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT BIOCHEM,DURHAM,NC 27710
关键词
D O I
10.1073/pnas.83.24.9408
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:9408 / 9412
页数:5
相关论文
共 27 条
[1]  
BENOVIC JL, 1985, J BIOL CHEM, V260, P7094
[2]   BETA-ADRENERGIC-RECEPTOR KINASE - IDENTIFICATION OF A NOVEL PROTEIN-KINASE THAT PHOSPHORYLATES THE AGONIST-OCCUPIED FORM OF THE RECEPTOR [J].
BENOVIC, JL ;
STRASSER, RH ;
CARON, MG ;
LEFKOWITZ, RJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (09) :2797-2801
[3]   RECONSTITUTION OF CATECHOLAMINE-STIMULATED GUANOSINETRIPHOSPHATASE ACTIVITY [J].
BRANDT, DR ;
ASANO, T ;
PEDERSEN, SE ;
ROSS, EM .
BIOCHEMISTRY, 1983, 22 (19) :4357-4362
[4]   THE MAMMALIAN BETA-2-ADRENERGIC RECEPTOR - RECONSTITUTION OF FUNCTIONAL INTERACTIONS BETWEEN PURE RECEPTOR AND PURE STIMULATORY NUCLEOTIDE BINDING-PROTEIN OF THE ADENYLATE-CYCLASE SYSTEM [J].
CERIONE, RA ;
CODINA, J ;
BENOVIC, JL ;
LEFKOWITZ, RJ ;
BIRNBAUMER, L ;
CARON, MG .
BIOCHEMISTRY, 1984, 23 (20) :4519-4525
[5]  
CLARK RB, 1985, J CYCLIC NUCL PROT, V10, P97
[6]  
HARDEN TK, 1983, PHARMACOL REV, V35, P5
[7]   RECEPTOR-SPECIFIC MECHANISMS OF DESENSITIZATION OF BETA-ADRENERGIC-RECEPTOR FUNCTION [J].
HERTEL, C ;
PERKINS, JP .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1984, 37 (03) :245-256
[8]   PROTEIN PHOSPHATASES - PROPERTIES AND ROLE IN CELLULAR-REGULATION [J].
INGEBRITSEN, TS ;
COHEN, P .
SCIENCE, 1983, 221 (4608) :331-338
[9]   FUNCTIONAL ALTERATION OF THE BETA-ADRENERGIC-RECEPTOR DURING DESENSITIZATION OF MAMMALIAN ADENYLATE-CYCLASE BY BETA-AGONISTS [J].
KASSIS, S ;
FISHMAN, PH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (21) :6686-6690
[10]  
KASSIS S, 1985, J BIOL CHEM, V260, P8911