P-1 ASPARTATE-BASED PEPTIDE ALPHA-((2,6-DICHLOROBENZOYL)OXY)METHYL KETONES AS POTENT TIME-DEPENDENT INHIBITORS OF INTERLEUKIN-1-BETA-CONVERTING ENZYME

被引：175

作者：

DOLLE, RE ^{[1
]}

HOYER, D ^{[1
]}

PRASAD, CVC ^{[1
]}

SCHMIDT, SJ ^{[1
]}

HELASZEK, CT ^{[1
]}

MILLER, RE ^{[1
]}

ATOR, MA ^{[1
]}

机构：

[1] STERLING WINTHROP PHARMACEUT, DIV RES, DEPT EZYMOL & RECEPTOR BIOCHEM, COLLEGEVILLE, PA 19426 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 05期

关键词：

D O I：

10.1021/jm00031a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：563 / 564

页数：2

共 22 条

[1] L-TRANS-EPOXYSUCCINYL-LEUCYLAMIDO(4-GUANIDINO)BUTANE (E-64) AND ITS ANALOGS AS INHIBITORS OF CYSTEINE PROTEINASES INCLUDING CATHEPSINS B, H AND L [J].

BARRETT, AJ ;

KEMBHAVI, AA ;

BROWN, MA ;

KIRSCHKE, H ;

KNIGHT, CG ;

TAMAI, M ;

HANADA, K .

BIOCHEMICAL JOURNAL, 1982, 201 (01) :189-198

[2]

BARRETT AJ, 1986, RES MONOG CELL TISSU, V12, P515

[3] ACTIVATION OF INTERLEUKIN-1-BETA BY A CO-INDUCED PROTEASE [J].

BLACK, RA ;

KRONHEIM, SR ;

SLEATH, PR .

FEBS LETTERS, 1989, 247 (02) :386-390

[4]

BLACK RA, 1988, J BIOL CHEM, V263, P9437

[5] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME [J].

CERRETTI, DP ;

KOZLOSKY, CJ ;

MOSLEY, B ;

NELSON, N ;

VANNESS, K ;

GREENSTREET, TA ;

MARCH, CJ ;

KRONHEIM, SR ;

DRUCK, T ;

CANNIZZARO, LA ;

HUEBNER, K ;

BLACK, RA .

SCIENCE, 1992, 256 (5053) :97-100

[6]

DINARELLO CA, 1991, BLOOD, V77, P1627

[7]

DINARELLO CA, 1993, NEW ENGL J MED, V328, P106

[8]

GRAYBILL T, IN PRESS INT J PEPTI

[9]

HENG R, 1993, Patent No. 9135

[10]

HOWARD AD, 1991, J IMMUNOL, V147, P2964

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