BRADYKININ-INDUCED ION CURRENTS IN CULTURED RAT TRIGEMINAL GANGLION-CELLS

被引：11

作者：

KITAKOGA, O ^{[1
]}

KUBA, K ^{[1
]}

机构：

[1] SAGA MED SCH,DEPT PHYSIOL,5-1-1 NABESHIMA,SAGA 849,JAPAN

来源：

NEUROSCIENCE RESEARCH | 1993年 / 16卷 / 02期

关键词：

BRADYKININ; CATION CURRENT; HYPERPOLARIZATION-ACTIVATED CURRENT; DELAYED RECTIFIER K+ CURRENT; SLOW VOLTAGE-DEPENDENT STEADY-STATE CURRENTS; RAT TRIGEMINAL GANGLION CELLS; WHOLE-CELL PATCH-CLAMP;

D O I：

10.1016/0168-0102(93)90075-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of bradykinin (BK) on membrane currents of cultured rat trigeminal ganglion cells were studied with a GOMEGA-sealed discontinuous voltage clamp technique. Bradykinin (0.05 nM-1 muM) produced membrane depolarization in most cells and hyperpolarization in some cells via a variety of ionic mechanisms: (1) activation of a cation current, (2) enhancement or (3) inhibition of a hyperpolarization-activated inwardly rectifying cation current known as I(H), (4) reduction or (5) enhancement of an outwardly rectifying outward current (presumably a delayed K+ current), (6) inhibition of a slow-gating voltage-dependent steady-state outward current (at > - 55 mV) and/or (7) increase in another slow-gating voltage-dependent outward current (at greater-than-or-equal-to - 70 mV). These components of BK-induced currents appeared in different combinations and extents among cells, explaining complex excitatory and modulatory actions of BK in different regions and types of sensory neurons.

引用

页码：79 / 93

页数：15

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