COMPLEMENT-MEDIATED KILLING OF BORRELIA-GARINII - BACTERICIDAL ACTIVITY OF WILD DEER SERUM

被引：8

作者：

ISOGAI, E

KAMEWAKA, Y

ISOGAI, H

KIMURA, K

FUJII, N

NISHIKAWA, T

机构：

[1] HLTH CTR RUMOI,SAPPORO,HOKKAIDO 077,JAPAN

[2] SAPPORO MED UNIV,CTR ANIM EXPERIMENTAT,SAPPORO,HOKKAIDO 060,JAPAN

[3] SAPPORO MED UNIV,DEPT MICROBIOL,SAPPORO,HOKKAIDO 060,JAPAN

[4] HOKKAIDO UNIV,SCH MED,DEPT DERMATOL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1994年 / 38卷 / 09期

关键词：

BORRELIA GARINII; COMPLEMENT-MEDIATED KILLING; ANTIBODY; WILD DEER SERUM;

D O I：

10.1111/j.1348-0421.1994.tb01852.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The susceptibility of Borrelia garinii to fresh wild deer sera was determined by incubating strain SIKA2 at 10% serum concentration for 1 hr at 37 C in an in vitro bactericidal assay. Each serum showed bactericidal effects at various levels. The effect was dependent on the concentration of antibody to the spirochetes. Complement was essential in the bactericidal assay because the inactivated deer serum showed greatly decreased activity. Our results suggest that B. garinii is sensitive to deer serum, in the presence of antibody and the bactericidal effect is important for preventing Lyme disease in wild sika deer.

引用

页码：753 / 756

页数：4

共 16 条

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