APPLICATION OF TANDEM MASS-SPECTROMETRY FOR THE ANALYSIS OF LONG-CHAIN CARBOXYLIC-ACIDS

被引：30

作者：

KUKSIS, A

MYHER, JJ

机构：

[1] Banting and Best Department of Medical Research, University of Toronto, Toronto

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 1995年 / 671卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0378-4347(95)00212-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of MS-MS for the analysis of long-chain carboxylic acids and their esters has proved enormously successful but expensive. It is discussed mainly on basis of results obtained with different instruments with lesser attention to principles of the method, which have been adequately reviewed elsewhere. The use of electrospray ionization (ESI) has greatly increased the sensitivity of the method and has permitted assay of total lipid extracts. The combination of HPLC with electrospray and single quadrupole mass spectrometry, LC-ESI-CID-MS, rivals the triple quadrupole MS-MS application in many instances at considerably lower cost. However, LC-ESI-MS-MS remains the most desirable system at the present time for lipid ester analyses.

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页码：35 / 70

页数：36

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