CCL4 CIRRHOSIS IN RATS - IRREVERSIBLE HISTOLOGICAL-CHANGES AND DIFFERENTIATED FUNCTIONAL IMPAIRMENT

被引:28
作者
FISCHERNIELSEN, A
POULSEN, HE
HANSEN, BA
HAGE, E
KEIDING, S
机构
[1] UNIV COPENHAGEN, RIGSHOSP, DEPT EXPTL PATHOL, DEPT MED A, DK-2100 COPENHAGEN, DENMARK
[2] UNIV COPENHAGEN, RIGSHOSP, DEPT PATHOL, DK-2100 COPENHAGEN, DENMARK
关键词
D O I
10.1016/0168-8278(91)90919-3
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Cirrhosis of the rate liver was induced by a 12 week individualized CCl4/phenobarbital treatment. After treatment, all surviving animals (81%) showed cirrhosis of the liver. The cirrhosis induced was irreversible when evaluated 24 weeks after cessation of treatment. Quantitative liver function measurements were reduced in differentiated manner. Ranked according to the most pronounced changes they are: capacity of urea-N synthesis (CUNS), galactose elimination capacity (GEC) and antipyrine clearance (APC). Hepatic glutathione concentrations were only slightly decreased after the CCl4 treatment. It is possible to produce a high incidence of irreversible cirrhosis with differentiated functional impairment in the rat.
引用
收藏
页码:110 / 117
页数:8
相关论文
共 25 条
[1]   INTERACTION BETWEEN ANTIPYRINE AND MICROSOMAL ETHANOL OXIDATION IN RAT-LIVER [J].
ANDREASEN, PB ;
BREMMELGAARD, A ;
LARSEN, BK .
PHARMACOLOGY, 1974, 12 (4-5) :244-250
[2]   MICROSOMAL PROTEIN-SYNTHESIS AND INDUCTION OF CYTOCHROME-P-450 IN CIRRHOTIC RAT-LIVER [J].
FARRELL, GC ;
ZALUZNY, L .
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 1984, 62 (JUN) :291-301
[3]   A RAPID AND PRECISE METHOD FOR THE DETERMINATION OF UREA [J].
FAWCETT, JK ;
SCOTT, JE .
JOURNAL OF CLINICAL PATHOLOGY, 1960, 13 (02) :156-159
[4]   AGE DEPENDENCE OF RAT-LIVER FUNCTION MEASUREMENTS [J].
FISCHERNIELSEN, A ;
POULSEN, HE ;
HANSEN, BA ;
TYGSTRUP, N ;
KEIDING, S .
JOURNAL OF HEPATOLOGY, 1989, 9 (02) :190-197
[5]   ESTIMATION OF TOTAL BODY WATER (VIRTUAL TRITIUM SPACE) IN THE RAT, CAT, RABBIT, GUINEA-PIG AND MAN, AND OF THE BIOLOGICAL HALF-LIFE OF TRITIUM IN MAN [J].
FOY, JM ;
SCHNIEDEN, H .
JOURNAL OF PHYSIOLOGY-LONDON, 1960, 154 (01) :169-176
[6]  
Goodwin JF, 1970, STAND METHODS CLIN C, V6, P89, DOI [10.1016/B978-0-12-609106-9.50014-2, DOI 10.1016/B978-0-12-609106-9.50014-2]
[7]   SPECTROPHOTOMETRIC DETERMINATION OF MICROGRAM QUANTITIES OF PROTEIN WITHOUT NUCLEIC ACID INTERFERENCE [J].
GROVES, WE ;
DAVIS, FC ;
SELLS, BH .
ANALYTICAL BIOCHEMISTRY, 1968, 22 (02) :195-&
[8]   CHANGES IN THE HEPATIC CAPACITY OF UREA-N SYNTHESIS, GALACTOSE ELIMINATION AND ANTIPYRINE CLEARANCE FOLLOWING 70-PERCENT HEPATECTOMY IN THE RAT [J].
HANSEN, BA ;
POULSEN, HE .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1986, 46 (03) :233-237
[9]   INCREASED INTESTINAL HYDROLYSIS OF UREA IN PATIENTS WITH ALCOHOLIC CIRRHOSIS [J].
HANSEN, BA ;
VILSTRUP, H .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1985, 20 (03) :346-350
[10]   THE CAPACITY OF UREA-N SYNTHESIS AS A QUANTITATIVE MEASURE OF THE LIVER MASS IN RATS [J].
HANSEN, BA ;
POULSEN, HE .
JOURNAL OF HEPATOLOGY, 1986, 2 (03) :468-474