EFFECTS OF CHRONIC FLUOXETINE TREATMENT ON BEHAVIORAL AND NEUROENDOCRINE RESPONSES TO META-CHLOROPHENYLPIPERAZINE IN OBSESSIVE-COMPULSIVE DISORDER

被引：110

作者：

HOLLANDER, E ^{[1
]}

DECARIA, C ^{[1
]}

GULLY, R ^{[1
]}

NITESCU, A ^{[1
]}

SUCKOW, RF ^{[1
]}

GORMAN, JM ^{[1
]}

KLEIN, DF ^{[1
]}

LIEBOWITZ, MR ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, DEPT CLIN PSYCHOBIOL, ANALYT PSYCHOPHARMACOL LAB, NEW YORK, NY 10032 USA

来源：

PSYCHIATRY RESEARCH | 1991年 / 36卷 / 01期

关键词：

OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN; FLUOXETINE; META-CHLOROPHENYLPIPERAZINE; ANXIETY DISORDERS;

D O I：

10.1016/0165-1781(91)90113-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

To investigate the effect of fluoxetine on serotonergic sensitivity in obsessive-compulsive disorder (OCD), the partial serotonin agonist metachlorophenylpiperazine (mCPP) was compared to placebo under double-blind conditions in six patients with OCD before and during treatment with fluoxetine. Readministration of oral mCPP (0.5 mg/kg) after at least 12 weeks of fluoxetine treatment did not increase obsessive-compulsive (OC) symptoms, in contrast to exacerbation of OC symptoms produced by mCPP before treatment. Chronic fluoxetine treatment resulted in a significant increase in prolactin and cortisol response to mCPP. This may be accounted for, however, by substantially increased plasma mCPP levels during fluoxetine treatment. Chronic fluoxetine treatment diminished the behavioral sensitivity to mCPP and did not diminish, but may have partially normalized, the neuroendocrine response to mCPP in patients with OCD. These adaptive homeostatic effects may reflect fluoxetine's antiobsessional mechanism.

引用

页码：1 / 17

页数：17

共 57 条

[1] NEUROENDOCRINE AND BEHAVIORAL-EFFECTS OF META-CHLOROPHENYLPIPERAZINE ADMINISTRATION IN RHESUS-MONKEYS [J].