EFFECT OF CLONIDINE ON CATECHOL METABOLISM IN THE ROSTRAL VENTROLATERAL MEDULLA - AN INVIVO ELECTROCHEMICAL STUDY

被引：37

作者：

MERMET, C

QUINTIN, L

机构：

[1] Laboratoire de Physiologie de L'Environnement (CNRS SDI 6100), Faculté de Médecine Grange-Blanche, Lyon

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 204卷 / 01期

关键词：

ROSTRAL VENTROLATERAL MEDULLA; VOLTAMMETRY; IMIDAZOLINE; ALPHA-2-ADRENOCEPTOR AGONISTS; CLONIDINE; ADRENALINE;

D O I：

10.1016/0014-2999(91)90842-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The dose-dependent reduction in catechol metabolism induced by an imidazoline with alpha-2-adrenoceptor agonist specificity, clonidine, was assessed (ED50 = 7-mu-g.kg-1 i.v.) with in vivo voltammetry in the rostral ventrolateral medulla of rats kept under halothane anesthesia and strictly controlled circulatory and ventilatory conditions. This reduction in catechol metabolism was observed in intact as well as in barodeafferented rats.

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页码：105 / 107

页数：3

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