BRAIN-SPECIFIC PROSTAGLANDIN-D2 SYNTHETASE MESSENGERRNA IS DEPENDENT ON THYROID-HORMONE DURING RAT-BRAIN DEVELOPMENT

被引：28

作者：

GARCIAFERNANDEZ, LF ^{[1
]}

INIGUEZ, MA ^{[1
]}

RODRIGUEZPENA, A ^{[1
]}

MUNOZ, A ^{[1
]}

BERNAL, J ^{[1
]}

机构：

[1] CSIC, INST INVEST BIOMED, ARTURO DUPERIER 4, E-28029 MADRID, SPAIN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.2262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously described several cDNA clones whose expression is affected by thyroid hormone during rat brain development. We now report the identification of one of these, the E2 clone, as the brain-specific prostaglandin D2 (PGD2) synthetase gene. Sequence comparison shows a nearly complete identity between the 356 nucleotides of the E2 clone and nucleotides 403 to 759 of PGD2 synthetase cDNA. The pattern of E2 expression corresponds to that expected for brain specific PGD2 synthetase gene, i.e. the corresponding mRNA is not detected in any other tissue analyzed apart of the brain, and it was present at different levels in all brain regions. Hypothyroidism decreased E2 mRNA concentrations in cerebral cortex and cerebellum. Control of the level of expression of PGD2 synthetase gene may contribute the complex effects of thyroid hormone on brain development and function. © 1993 Academic Press, Inc.

引用

页码：396 / 401

页数：6

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