NOC, A NITRIC-OXIDE-RELEASING COMPOUND, INDUCES DOSE-DEPENDENT APOPTOSIS IN MACROPHAGES

被引：71

作者：

SHIMAOKA, M

IIDA, T

OHARA, A

TAENAKA, N

MASHIMO, T

HONDA, T

YOSHIYA, I

机构：

[1] OSAKA UNIV HOSP,INTENS CARE UNIT,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT ANESTHESIOL,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of exogenous nitric oxide (NO) to induce apoptosis in macrophages was analyzed using NOC, a NO-releasing compound, as a source of NO. Exogenous NO was shown to induce apoptosis in a dose dependent manner. Quantitative analysis revealed that the amount of NO required to induce apoptosis in more than half of macrophages exposed was 100 times larger than that for endogenous NO-induced apoptosis. NOC proved to be a convenient and useful tool for investigation of apoptosis related to NO. (C) 1995 Academic Press, Inc.

引用

收藏

页码：519 / 526

页数：8

相关论文

共 23 条

[1]

ALBINA JE, 1993, J IMMUNOL, V150, P5080

[2] INTERLEUKIN-1 IS PROCESSED AND RELEASED DURING APOPTOSIS [J].

HOGQUIST, KA ;

NETT, MA ;

UNANUE, ER ;

CHAPLIN, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8485-8489

[3] NEW NITRIC OXIDE-RELEASING ZWITTERIONS DERIVED FROM POLYAMINES [J].

HRABIE, JA ;

KLOSE, JR ;

WINK, DA ;

KEEFER, LK .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (06) :1472-1476

[4] BORDETELLA-PERTUSSIS INDUCES APOPTOSIS IN MACROPHAGES - ROLE OF ADENYLATE CYCLASE-HEMOLYSIN [J].

KHELEF, N ;

ZYCHLINSKY, A ;

GUISO, N .

INFECTION AND IMMUNITY, 1993, 61 (10) :4064-4071

[5] LOW-DOSE INHALATIONAL NITRIC-OXIDE IN PERSISTENT PULMONARY-HYPERTENSION OF THE NEWBORN [J].

KINSELLA, JP ;

NEISH, SR ;

SHAFFER, E ;

ABMAN, SH .

LANCET, 1992, 340 (8823) :819-820

[6] ERYTHROPOIETIN RETARDS DNA BREAKDOWN AND PREVENTS PROGRAMMED DEATH IN ERYTHROID PROGENITOR CELLS [J].

KOURY, MJ ;

BONDURANT, MC .

SCIENCE, 1990, 248 (4953) :378-381

[7]

MARAGOS CM, 1993, CANCER RES, V53, P564

[8] PROGRAMMED DEATH OF T-CELLS IN HIV-1 INFECTION [J].

MEYAARD, L ;

OTTO, SA ;

JONKER, RR ;

MIJNSTER, MJ ;

KEET, RPM ;

MIEDEMA, F .

SCIENCE, 1992, 257 (5067) :217-219

[9] EFFECT OF INHALED NITRIC-OXIDE ON HEMODYNAMICS AND V-A/Q INEQUALITIES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].

MOINARD, J ;

MANIER, G ;

PILLET, O ;

CASTAING, Y .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (06) :1482-1487

[10] THE APOPTOSIS-1 FAS PROTEIN IN HUMAN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

MYSLER, E ;

BINI, P ;

DRAPPA, J ;

RAMOS, P ;

FRIEDMAN, SM ;

KRAMMER, PH ;

ELKON, KB .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1029-1034