THE EFFECT OF ISLET AMYLOID POLYPEPTIDE (AMYLIN) AND CALCITONIN GENE-RELATED PEPTIDE ON GLUCOSE REMOVAL IN THE ANESTHETIZED RAT AND ON INSULIN-SECRETION FROM RAT PANCREATIC-ISLETS INVITRO

The effect of intravenous infusion of islet amyloid polypeptide (IAPP/amylin) and calcitonin gene-related peptide (CGRP) on blood glucose and plasma insulin in the basal and glucose-stimulated state was investigated in the anaesthetized rat. Both peptides had no effect on basal blood glucose or plasma insulin but following an intravenous bolus of glucose, CGRP-treated rats were hyperglycaemic and hyperinsulinaemic compared with control animals which were similar to IAPP-treated rats. IAPP had no effect on glucose-stimulated islet insulin secretion. These results suggest that CGRP, but not IAPP, alters glucose removal in vivo. © 1990 Plenum Publishing Corporation.