LORACARBEF (LY163892) VERSUS AMOXICILLIN-CLAVULANATE IN THE TREATMENT OF BACTERIAL ACUTE OTITIS-MEDIA WITH EFFUSION

被引:21
作者
FOSHEE, WS [1 ]
机构
[1] MED COLL GEORGIA, DEPT PEDIAT, AUGUSTA, GA 30912 USA
关键词
D O I
10.1016/S0022-3476(05)81974-2
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The efficacy and safety of loracarbef, a new beta-lactam antibiotic, was compared with that of amoxicillin-clavulanate potassium in the treatment of bacterial acute otitis media with effusion. A double-blind format was utilized to administer 10-day, randomized, parallel treatment regimens to patients who were between 6 months and 12 years of age. The most prevalent causative pathogens found in the two treatment groups were Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella (Branhamella) catarrhalis. The percentages of favorable posttherapy clinical responses in evaluable patients were similar for both drugs: 87.3% (124/142) of the loracarbef group, compared with 91.5% (130/142) of the amoxicillin-clavulanate group, showed favorable responses within 72 hours after treatment. Ten to sixteen days after treatment, 68.1% of the loracarbef group, compared with 76.1% of the amoxicillin-clavulanate group, showed favorable responses. More patients in the amoxicillin-clavulanate group reported treatment-emergent events: 46.1% compared with 35.8% in the loracarbef group (p = 0.023). Diarrhea was the most frequently reported event, occurring in 13.3% of the loracarbef group and in 26.3% of the amoxicillin-clavulanate group (p <0.001). Vomiting was reported by 5.8% of the loracarbef group and 10.3% of the amoxicillin-clavulanate group (p = 0.072). Loracarbef is comparable in efficacy to amoxicillin-clavulanate in the treatment of bacterial acute otitis media with effusion and has a more desirable safety profile.
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页码:980 / 986
页数:7
相关论文
共 12 条
[1]   COMPARATIVE REACTIVITY OF 1-CARBA-1-DETHIACEPHALOSPORINS WITH CEPHALOSPORINS [J].
BLASZCZAK, LC ;
BROWN, RF ;
COOK, GK ;
HORNBACK, WJ ;
HOYING, RC ;
INDELICATO, JM ;
JORDAN, CL ;
KATNER, AS ;
KINNICK, MD ;
MCDONALD, JH ;
MORIN, JM ;
MUNROE, JE ;
PASINI, CE .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (06) :1656-1662
[3]   3-SULFONYL-1-CARBA-1-DETHIACEPHEMS [J].
CROWELL, TA ;
HALLIDAY, BD ;
MCDONALD, JH ;
INDELICATO, JM ;
PASINI, CE ;
WU, ECY .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (11) :2436-2442
[4]   THE EFFECT OF PRESCRIBED DAILY DOSE FREQUENCY ON PATIENT MEDICATION COMPLIANCE [J].
EISEN, SA ;
MILLER, DK ;
WOODWARD, RS ;
SPITZNAGEL, E ;
PRZYBECK, TR .
ARCHIVES OF INTERNAL MEDICINE, 1990, 150 (09) :1881-1884
[5]  
FEIGIN RD, 1987, TXB PEDIATRIC INFECT, P198
[6]   ACUTE OTITIS MEDIA IN CHILDREN - BACTERIOLOGICAL FINDINGS IN MIDDLE EAR FLUID OBTAINED BY NEEDLE ASPIRATION [J].
FEINGOLD, M ;
KLEIN, JO ;
HASLAM, GE ;
TILLES, JG ;
FINLAND, M ;
GELLIS, SS .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1966, 111 (04) :361-&
[7]   5 VS 10 DAYS OF THERAPY FOR ACUTE OTITIS-MEDIA [J].
HENDRICKSE, WA ;
KUSMIESZ, H ;
SHELTON, S ;
NELSON, JD .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1988, 7 (01) :14-23
[8]   BETA-LACTAMASE HYDROLYSIS AND INHIBITION STUDIES OF THE NEW 1-CARBACEPHEM LY163892 [J].
JONES, RN ;
BARRY, AL .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1987, 6 (05) :570-571
[9]   AMOXICILLIN-CLAVULANATE POTASSIUM COMPARED WITH CEFACLOR FOR ACUTE OTITIS-MEDIA IN INFANTS AND CHILDREN [J].
KALEIDA, PH ;
BLUESTONE, CD ;
ROCKETTE, HE ;
BASS, LW ;
WOLFSON, JH ;
BRECK, JM ;
UBINGER, EB ;
ROHN, DD .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1987, 6 (03) :265-271
[10]   INVITRO ACTIVITIES OF LY163892, CEFACLOR, AND CEFUROXIME [J].
KNAPP, CC ;
WASHINGTON, JA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (01) :131-133