DETERMINATION OF THIOL-CONTAINING DRUGS BY CHEMILUMINESCENCE FLOW-INJECTION ANALYSIS

被引：44

作者：

VINAS, P

GARCIA, IL

GIL, JAM

机构：

[1] Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 01期

关键词：

CHEMILUMINESCENCE; FLOW INJECTION ANALYSIS; CYSTEINE; N-ACETYLCYSTEINE; PENICILLAMINE; 2-MERCAPTOPROPIONYLGLYCINE; THIOURACIL;

D O I：

10.1016/0731-7085(93)80144-P

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A flow injection analysis procedure with chemiluminescence detection for the determination of both thiol-containing drugs and the amino acid cysteine is described. Procedures are based on the inhibition by the drugs of the chemiluminescence generated in the copper-catalysed oxidation of luminol by hydrogen peroxide. The proposed methods were applied to the determination of cysteine, N-acetylcysteine, penicillamine, 2-mercaptopropionylglycine and thiouracil in pharmaceuticals.

引用

页码：15 / 20

页数：6

共 17 条

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