THE ANALYSIS OF MODIFIED PEROXISOME PROLIFERATOR RESPONSIVE ELEMENTS OF THE PEROXISOMAL BIFUNCTIONAL ENZYME IN TRANSFECTED HEPG2 CELLS REVEALS 2 REGULATORY MOTIFS

被引：17

作者：

BARDOT, O ^{[1
]}

CLEMENCET, MC ^{[1
]}

PASSILLY, P ^{[1
]}

LATRUFFE, N ^{[1
]}

机构：

[1] UNIV BOURGOGNE,LBMC,F-21004 DIJON,FRANCE

来源：

FEBS LETTERS | 1995年 / 360卷 / 02期

关键词：

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR RESPONSE ELEMENT; 9-CIS RETINOIC ACID RECEPTOR ALPHA; RAT PEROXISOMAL ENOYL-COA HYDRATASE/3-HYDROXYACYL-COA DEHYDROGENASE; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.1016/0014-5793(95)00097-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferators (PPs) are non-genotoxic carcinogens in rodents, They can induce the expression of numerous genes via the heterodimerization of two members of the steroid hormone receptor superfamily, called the peroxisome proliferator-activated receptor (PPAR) and the 9-cis retinoic acid receptor (RXR). Many of the PP responsive genes possess a peroxisome proliferator response element (PPRE) formed by two TGACCT-related motifs. The bifunctional enzyme (HD) PPRE contains 3 such motifs, creating DR1 and DR2 sequences. PPAR and RXR regulate transcription via the DR1 element while DR2 modulates the expression of the gene via auxiliary factors in HepG2 cells.

引用

页码：183 / 186

页数：4

共 18 条

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