Developmental effects of dioxins and related endocrine disrupting chemicals

被引：100

作者：

Birnbaum, LS

机构：

[1] Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); dioxins; polychlorinated biphenyls (PCBs); developmental toxicity; endocrine disruption; receptor-mediated toxicity;

D O I：

10.1016/0378-4274(95)03592-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Alteration of hormones has long been known to affect development. TCDD and related PHAHs modulate the levels of many hormonal systems. Dioxins cause a spectrum of morphological and functional developmental deficits. Fetotoxicity, thymic atrophy, and structural malformations are often noted. Delayed genitourinary tract effects have been observed, and recent studies reported behavioral effects. Highly exposed human offspring have exhibited developmental problems as well. Recently, hormonal and neurological abnormalities have been reported in infants from the general population. The complex alteration of multiple endocrine systems is likely associated with the spectrum of adverse developmental effects caused by dioxin and related compounds.

引用

页码：743 / 750

页数：8

共 61 条

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