NEUTRON-CAPTURE THERAPY OF MURINE ASCITES TUMOR WITH GADOLINIUM-CONTAINING MICROCAPSULES

被引：28

作者：

AKINE, Y

TOKITA, N

TOKUUYE, K

SATOH, M

FUKUMORI, Y

TOKUMITSU, H

KANAMORI, R

KOBAYASHI, T

KANDA, K

机构：

[1] NATL CANC CTR,DEPT RADIAT THERAPY,TOKYO 104,JAPAN

[2] KOBE GAKUIN UNIV,FAC PHARMACEUT SCI,KOBE 673,JAPAN

[3] ITAMI MUNICIPAL HOSP,DEPT PHARMACEUT,ITAMI,JAPAN

[4] KYOTO UNIV,INST RES REACTOR,KYOTO 606,JAPAN

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1992年 / 119卷 / 02期

关键词：

NEUTRON CAPTURE THERAPY; GADOLINIUM; EHRLICH ASCITES TUMOR; MICROCAPSULES;

D O I：

10.1007/BF01209658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gadolinium-containing microcapsules were evaluated as an agent for gadolinium neutron-capture therapy. Mice were inoculated intraperitoneally with 10(7) Ehrlich ascites tumor cells and gadolinium microcapsules and exposed to thermal neutrons for 12 min (approximately 1.86x10(12) neutrons cm-2). Significantly more mice given gadolinium microcapsules than those given placebo microcapsules or control survived for 60 days and considerably longer (P<0.0001), indicating that gadolinium neutron-capture reactions effectively suppressed the growth of ascites tumor cells in mice. The results suggest that these microcapsules are an effective gadolinium carrier for neutron-capture therapy.

引用

页码：71 / 73

页数：3

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