COEXPRESSION OF GLYCINE RECEPTOR BETA-SUBUNIT AND GABA-A RECEPTOR GAMMA-SUBUNIT MESSENGER-RNA IN THE RAT DORSAL-ROOT GANGLION-CELLS

被引：35

作者：

FURUYAMA, T ^{[1
]}

SATO, M ^{[1
]}

SATO, K ^{[1
]}

ARAKI, T ^{[1
]}

INAGAKI, S ^{[1
]}

TAKAGI, H ^{[1
]}

TOHYAMA, M ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI 2,OSAKA,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 12卷 / 04期

关键词：

COEXPRESSION; GLYCINE RECEPTOR; GABA-A RECEPTOR; DORSAL ROOT GANGLION; LARGE NEURON; MECHANORECEPTOR; INSITU HYBRIDIZATION;

D O I：

10.1016/0169-328X(92)90136-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the expression of the beta-subunit mRNA of the glycine receptor and the gamma-subunit mRNA of the GABA(A) receptor in the rat dorsal root ganglion (DRG) using in situ hybridization histochemistry with oligonucleotide probes. About 44% and 37% of the all DRG neurons were labeled by the probes for glycine receptor beta-subunit and GABA(A) receptor gamma-subunit mRNAs. Labeled neurons were mostly large cells that simultaneously expressed both glycine receptor beta-subunit and GABA(A) receptor gamma-subunit mRNA as demonstrated using consecutive sections. Thus, we suggest the possibility that both GABA and glycine presynaptically regulate the activity of neurons involved in low-threshold mechanoreception at axo-axonic synapses in the spinal cord.

引用

页码：335 / 338

页数：4

共 17 条

[1]

ARAKI T, 1991, NEUROSCI RES S, V14, P138

[2] GABAERGIC TERMINALS ARE PRESYNAPTIC TO PRIMARY AFFERENT TERMINALS IN SUBSTANTIA GELATINOSA OF RAT SPINAL-CORD [J].

BARBER, RP ;

VAUGHN, JE ;

SAITO, K ;

MCLAUGHLIN, BJ ;

ROBERTS, E .

BRAIN RESEARCH, 1978, 141 (01) :35-55

[3] DISTRIBUTION OF GLYCINE RECEPTOR IMMUNOREACTIVITY IN THE SPINAL-CORD OF THE RAT - CYTOCHEMICAL EVIDENCE FOR A DIFFERENTIAL GLYCINERGIC CONTROL OF LAMINA-I AND LAMINA-V NOCICEPTIVE NEURONS [J].

BASBAUM, AI .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 278 (03) :330-336

[4] GLYCINE NEURONS IN THE BRAIN AND SPINAL-CORD - ANTIBODY-PRODUCTION AND IMMUNOCYTOCHEMICAL LOCALIZATION [J].

CAMPISTRON, G ;

BUIJS, RM ;

GEFFARD, M .

BRAIN RESEARCH, 1986, 376 (02) :400-405

[5]

GREENINGLOH G, 1990, NEURON, V4, P963

[6] A NOXIOUS STIMULUS INDUCES THE PREPROTACHYKININ-A GENE-EXPRESSION IN THE RAT DORSAL-ROOT GANGLION - A QUANTITATIVE STUDY USING INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

NOGUCHI, K ;

MORITA, Y ;

KIYAMA, H ;

ONO, K ;

TOHYAMA, M .

MOLECULAR BRAIN RESEARCH, 1988, 4 (01) :31-35

[7]

OTTERSEN OP, 1987, J MIND BEHAV, V8, P503

[8] NEUROTRANSMITTER CANDIDATES OF SOMATOSENSORY PRIMARY AFFERENT-FIBERS [J].

SALT, TE ;

HILL, RG .

NEUROSCIENCE, 1983, 10 (04) :1083-+

[9] LOCALIZATION OF GLYCINE RECEPTOR ALPHA-1 SUBUNIT MESSENGER RNA-CONTAINING NEURONS IN THE RAT-BRAIN - AN ANALYSIS USING INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

SATO, K ;

ZHANG, JH ;

SAIKA, T ;

SATO, M ;

TADA, K ;

TOHYAMA, M .

NEUROSCIENCE, 1991, 43 (2-3) :381-395

[10] DIFFERENT ONTOGENIC PROFILES OF CELLS EXPRESSING PREPRONEUROTENSIN NEUROMEDIN-N MESSENGER-RNA IN THE RAT POSTERIOR CINGULATE CORTEX AND THE HIPPOCAMPAL-FORMATION [J].

SATO, M ;

LEE, Y ;

ZHANG, JH ;

SHIOSAKA, S ;

NOGUCHI, K ;

MORITA, Y ;

TOHYAMA, M .

DEVELOPMENTAL BRAIN RESEARCH, 1990, 54 (02) :249-255

← 1 2 →