TOTAL SYNTHESIS OF THIANGAZOLE, A NOVEL NATURALLY-OCCURRING HIV-1 INHIBITOR FROM POLYANGIUM SP

被引：49

作者：

BOYCE, RJ ^{[1
]}

MULQUEEN, GC ^{[1
]}

PATTENDEN, G ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 26期

关键词：

D O I：

10.1016/0040-4020(95)00356-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the cinnamyl-oxazole substituted tris-thiazoline containing metabolite (-)-thiangazole (1) is described. The synthesis is based on elaboration of the R-2-methylcysteine derived bis-thiazoline nitrile (5) and oxazole (6) intermediates, followed by a cyclocondensation reaction between (5) and (6), and treatment of the resulting tris-thiazoline oxazole ester (16) with methylamine.

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页码：7321 / 7330

页数：10

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