IMMUNOPHENOTYPE OF LYMPHOCYTES IN PERICARDIAL FLUID FROM PATIENTS WITH DIFFERENT FORMS OF HEART-DISEASE

被引:32
作者
RIEMANN, D [1 ]
WOLLERT, HG [1 ]
MENSCHIKOWSKI, J [1 ]
MITTENZWEI, S [1 ]
LANGNER, J [1 ]
机构
[1] UNIV HALLE WITTENBERG, DEPT HEART SURG, D-06097 HALLE, GERMANY
关键词
PERICARDIAL FLUID; LYMPHOCYTES; IMMUNOPHENOTYPE; AMINOPEPTIDASE N; HLA-DR; CD11B; CD69;
D O I
10.1159/000236708
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Cytofluorometric analysis was performed to characterize the immunophenotype of lymphocytes of the pericardial fluid (PF) from 127 patients undergoing open cardiac operation (heart valve disease, congenital heart defects, chronic ischemic heart disease). Macrophages and T cells represented the dominant cell types. Similar to T cells of body fluids other than peripheral blood, a high percentage of PF T cells expressed CD45RO and activation-associated molecules such as HLA-DR, CD69,CD54 and CD26. Surprisingly, we could demonstrate a very high proportion of CD11b+ T cells in PE Furthermore, a significant proportion of PF T cells expressed aminopeptidase N/CD13. PF was further analyzed for the presence of IL-6, TGF-(beta as well as TNF-alpha. IL-6 levels were low (undetectable to 4,500 U/ml), TGF-beta levels ranged from <3 ng/ml up to 80 ng/ml, and TNF-alpha levels from <3 pg/ml to 233 pg/ml. These findings show evidence of the presence of activated lymphocytes with a special immunophenotype as well as multiple cytokines in PF of patients with different forms of heart disease.
引用
收藏
页码:48 / 56
页数:9
相关论文
共 44 条
[1]  
AHUJA SS, 1993, J IMMUNOL, V150, P3109
[2]   PREDOMINANCE OF MEMORY T-CELLS (CD4+, CDW29+) OVER NAIVE T-CELLS (CD4+, CD45R+) IN BOTH NORMAL AND DISEASED HUMAN-SKIN [J].
BOS, JD ;
HAGENAARS, C ;
DAS, PK ;
KRIEG, SR ;
VOORN, WJ ;
KAPSENBERG, ML .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1989, 281 (01) :24-30
[3]   CD16 - DEVELOPMENTALLY REGULATED IGG FC-RECEPTORS ON CULTURED HUMAN-MONOCYTES [J].
CLARKSON, SB ;
ORY, PA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (02) :408-417
[4]   THE INTRINSIC MIGRATORY CAPACITY OF MEMORY T-CELLS CONTRIBUTES TO THEIR ACCUMULATION IN RHEUMATOID SYNOVIUM [J].
CUSH, JJ ;
PIETSCHMANN, P ;
OPPENHEIMERMARKS, N ;
LIPSKY, PE .
ARTHRITIS AND RHEUMATISM, 1992, 35 (12) :1434-1444
[5]   PHENOTYPIC ANALYSIS OF SYNOVIAL TISSUE AND PERIPHERAL-BLOOD LYMPHOCYTES ISOLATED FROM PATIENTS WITH RHEUMATOID-ARTHRITIS [J].
CUSH, JJ ;
LIPSKY, PE .
ARTHRITIS AND RHEUMATISM, 1988, 31 (10) :1230-1238
[6]   IMMUNODETECTION AND QUANTITATION OF THE 2 FORMS OF TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA-1 AND TGF-BETA-2) SECRETED BY CELLS IN CULTURE [J].
DANIELPOUR, D ;
DART, LL ;
FLANDERS, KC ;
ROBERTS, AB ;
SPORN, MB .
JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (01) :79-86
[7]   A CELL-SURFACE MOLECULE INVOLVED IN ORGAN-SPECIFIC HOMING OF LYMPHOCYTES [J].
GALLATIN, WM ;
WEISSMAN, IL ;
BUTCHER, EC .
NATURE, 1983, 304 (5921) :30-34
[8]  
HAMANN J, 1993, J IMMUNOL, V150, P4920
[9]  
HANAWA H, 1993, J IMMUNOL, V150, P5682
[10]   FUNCTIONAL DISCRIMINATION BETWEEN INTERLEUKIN-6 AND INTERLEUKIN-1 [J].
HELLE, M ;
BOEIJE, L ;
AARDEN, LA .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (10) :1535-1540