UK PROSPECTIVE DIABETES STUDY (UKPDS) .14. ASSOCIATION OF ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION POLYMORPHISM WITH MYOCARDIAL-INFARCTION IN NIDDM

被引：30

作者：

KEAVNEY, BD

DUDLEY, CRK

STRATTON, IM

HOLMAN, RR

MATTHEWS, DR

RATCLIFFE, PJ

TURNER, RC

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT MED,OXFORD OX3 9DU,ENGLAND

[2] RADCLIFFE INFIRM,DIABET RES LABS,OXFORD OX2 6HE,ENGLAND

来源：

DIABETOLOGIA | 1995年 / 38卷 / 08期

关键词：

NON-INSULIN-DEPENDENT DIABETES MELLITUS; MYOCARDIAL INFARCTION; ANGIOTENSIN-CONVERTING ENZYME; GENETICS; RISK FACTORS;

D O I：

10.1007/BF00400584

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The deletion allele of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene has been suggested to be an independent risk factor for myocardial infarction, particularly in subjects judged to be ''low-risk'' by the criteria of lipid status and body mass index. In a prospective, matched case-control study, we have investigated the role of this polymorphism as a risk factor for myocardial infarction in 173 newly-diagnosed British Caucasian non-insulin-dependent diabetic subjects taken from the United Kingdom Prospective Diabetes Study who subsequently developed myocardial infarction and 297 control subjects from the same study population matched for known cardiovascular risk factors including age at diagnosis of diabetes, gender, blood pressure, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and smoking habit. A trend towards increased risk conferred by homozygosity for the deletion allele was observed in cases (odds ratio 1.63, p = 0.09). When the population was stratified according to the matched risk factors, the deletion allele was associated with myocardial infarction in those with low plasma low-density lipoprotein cholesterol (odds ratio 3.67, p = 0.002), or low triglyceride (odds ratio 3.14, p = 0.005). The strongest association of the deletion allele with myocardial infarction was observed in subjects with both low low-density lipoprotein cholesterol and low triglyceride levels (odds ratio 9.0, p < 0.001). These results show that the deletion allele is a risk factor for myocardial infarction in non-insulin-dependent diabetic patients who have a favourable lipid profile.

引用

页码：948 / 952

页数：5

共 16 条

[1] Cambien F., Alhenc-Gelas F., Herbeth B., Et al., Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy study, Am J Hum Genet, 38, pp. 228-234, (1988)
[2] Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F., An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels, J Clin Invest, 14, pp. 1343-1346, (1990)
[3] Tiret L., Rigat B., Visvikis S., Et al., Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme gene controls plasma ACE levels, Am J Hum Genet, 51, pp. 197-205, (1992)
[4] Cambien F., Poirier O., Lecerf L., Et al., Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction, Nature, 359, pp. 641-644, (1992)
[5] Tiret L., Kee F., Poirier O., Et al., Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction, Lancet, 341, pp. 991-992, (1993)
[6] Evans A.E., Poirier O., Kee F., Et al., Polymorphisms of the angiotensin-converting enzyme gene in subjects who die from coronary heart disease, Quart J Med, 87, pp. 211-214, (1994)
[7] Ruiz J., Blanche H., Cohen N., Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus, Proc Natl Acad Sci USA, 91, pp. 3662-3665, (1994)
[8] Bohn M., Berge K.E., Bakken A., Erikssen J., Berg K., Insertion/deletion polymorphism at the locus for angiotensinogen I-converting enzyme and myocardial infarction, Clin Genet, 44, pp. 292-297, (1993)
[9] UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance, Diabetologia, 34, pp. 877-890, (1991)
[10] Rigat B., Hubert C., Corvol P., Soubrier F., PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1), Nucleic Acids Res, 20, (1992)

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