SYNTHESIS AND CARDIOTONIC ACTIVITY OF PYRIMIDO[5,4-B][1,4]OXAZINONES AND 1,4-DIOXINO[2,3-D]PYRIMIDINES

被引：7

作者：

MATYUS, P

MAKK, N

TEGDES, A

KOSARY, J

KASZTREINER, E

PODANYI, B

RABLOCZKY, G

KURTHY, M

机构：

[1] Institute for Drug Research, Budapest, H-1325

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 02期

关键词：

D O I：

10.1002/jhet.5570270207

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new pyrimido[5,4‐b][1,4]oxazinones 4a‐c and 6a,b, 7a,c were obtained from 6‐amino‐2,3‐dimethyl‐4(3H)‐pyrimidone (1) and 4‐substituted pyrimido[5,4–6][1,4]oxazinones 5, 7a, respectively, while derivatives 8a‐e of the novel ring system 1,4‐dioxino[2,3‐d]pyrimidine were prepared starting from 2b. Compounds 4a, 4c and 7a showed positive inotropic effect. Copyright © 1990 Journal of Heterocyclic Chemistry

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页码：151 / 155

页数：5

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