MITOGENIC RESPONSE TO COLONY-STIMULATING FACTOR-I

被引：61

作者：

SHERR, CJ

机构：

[1] Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, NJ 38105

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 11-12期

关键词：

D O I：

10.1016/0168-9525(91)90263-P

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The proliferative effects of colony-stimulating factor 1 (CSF-1) on cells of the mononuclear phagocyte lineage are mediated by the CSF-1 receptor tyrosine kinase, which triggers intracellular signal transduction through multiple second messenger pathways. CSF-1 is required throughout G1 to stimulate both immediate- and delayed-early responses that ensure entry of macrophages into S phase. Because CSF-1 induces the expression of different sets of cellular genes during early and late G1, products of the immediate-early response might modulate the effects of ensuing receptor signals to facilitate G1 progression. Targets of the delayed-early response include novel cyclin genes that may play a role in S phase commitment.

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页码：398 / 402

页数：5

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