DIHYDROPYRIDINONE APPROACH TO MANZAMINES - AN EXPEDIENT CONSTRUCTION OF THE TETRACYCLIC CORE OF MANZAMINE-A

被引：47

作者：

NAKAGAWA, M ^{[1
]}

TORISAWA, Y ^{[1
]}

HOSAKA, T ^{[1
]}

TANABE, K ^{[1
]}

DATE, T ^{[1
]}

OKAMURA, K ^{[1
]}

HINO, T ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD,ORGAN CHEM RES LAB,TODA,SAITAMA 335,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 28期

关键词：

D O I：

10.1016/0040-4039(93)88081-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A construction of the central tetracyclic core (19) of manzamine A (1) was successfully achieved by a highly efficient Diels-Alder reaction of the suitably protected dihydropyridinones (5) and Danishefsky's diene as a key strategy. Expedient conversion of the D-A product (7) to the precursor (15) was followed by the azocine lactam ring closure to furnish the titled core.

引用

页码：4543 / 4546

页数：4

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