A PROPOSED FUNCTION FOR SPERMINE AND SPERMIDINE - PROTECTION OF REPLICATING DNA AGAINST DAMAGE BY SINGLET OXYGEN

被引：131

作者：

KHAN, AU ^{[1
]}

MEI, YH ^{[1
]}

WILSON, T ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 23期

关键词：

SINGLET OXYGEN QUENCHING; POLYAMINES;

D O I：

10.1073/pnas.89.23.11426

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Like all aliphatic amines, the polyamines spermine and spermidine are physical quenchers of singlet molecular oxygen (O-1(2)*). The rate constants of these processes were determined in vitro with photochemically generated O-1(2)* and the hydrocarbon rubrene as substrate, in pyridine. At millimolar concentration, spermine and spermidine should quench O-1(2)* in vivo and prevent it from damaging DNA. It is proposed that a biological function of polyamines is the protection of replicating DNA against oxidative damage.

引用

页码：11426 / 11427

页数：2

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