MASKING OF THE CBF1/RBPJ(KAPPA) TRANSCRIPTIONAL REPRESSION DOMAIN BY EPSTEIN-BARR-VIRUS EBNA2

被引：266

作者：

HSIEH, JJD

HAYWARD, SD

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PHARMACOL & MOLEC SCI, MOLEC VIROL LABS, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, MD 21205 USA

来源：

SCIENCE | 1995年 / 268卷 / 5210期

关键词：

D O I：

10.1126/science.7725102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2 binding. Thus, EBNA2 acts by countering transcriptional repression. Mutation at amino acid 233 of CBF1 abolishes repression and correlates with a loss-of-function mutation in the Drosophila homolog Su(H).

引用

收藏

页码：560 / 563

页数：4

相关论文

共 25 条

[1] HUMAN-JK RECOMBINATION SIGNAL BINDING-PROTEIN GENE (IGKJRB) - COMPARISON WITH ITS MOUSE HOMOLOG [J].

AMAKAWA, R ;

JING, W ;

OZAWA, K ;

MATSUNAMI, N ;

HAMAGUCHI, Y ;

MATSUDA, F ;

KAWAICHI, M ;

HONJO, T .

GENOMICS, 1993, 17 (02) :306-315

[2] EPSTEIN-BARR-VIRUS (EBV) INDUCES EXPRESSION OF B-CELL ACTIVATION MARKERS ON INVITRO INFECTION OF EBV-NEGATIVE B-LYMPHOMA CELLS [J].

CALENDER, A ;

BILLAUD, M ;

AUBRY, JP ;

BANCHEREAU, J ;

VUILLAUME, M ;

LENOIR, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (22) :8060-8064

[3] EPSTEIN-BARR VIRUS NUCLEAR PROTEIN-2 IS A KEY DETERMINANT OF LYMPHOCYTE-TRANSFORMATION [J].

COHEN, JI ;

WANG, F ;

MANNICK, J ;

KIEFF, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9558-9562

[4] REPRESSION VERSUS ACTIVATION IN THE CONTROL OF GENE-TRANSCRIPTION [J].

COWELL, IG .

TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (01) :38-42

[5] THE RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN RBP-2N FUNCTIONS AS A TRANSCRIPTIONAL REPRESSOR [J].

DOU, SB ;

ZENG, XO ;

CORTES, P ;

ERDJUMENTBROMAGE, H ;

TEMPST, P ;

HONJO, T ;

VALES, LD .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3310-3319

[6] TAN-1, THE HUMAN HOMOLOG OF THE DROSOPHILA NOTCH GENE, IS BROKEN BY CHROMOSOMAL TRANSLOCATIONS IN T-LYMPHOBLASTIC NEOPLASMS [J].

ELLISEN, LW ;

BIRD, J ;

WEST, DC ;

SORENG, AL ;

REYNOLDS, TC ;

SMITH, SD ;

SKLAR, J .

CELL, 1991, 66 (04) :649-661

[7] THE SUPPRESSOR OF HAIRLESS PROTEIN PARTICIPATES IN NOTCH RECEPTOR SIGNALING [J].

FORTINI, ME ;

ARTAVANISTSAKONAS, S .

CELL, 1994, 79 (02) :273-282

[8] THE DROSOPHILA HOMOLOG OF THE IMMUNOGLOBULIN RECOMBINATION SIGNAL BINDING-PROTEIN REGULATES PERIPHERAL NERVOUS-SYSTEM DEVELOPMENT [J].

FURUKAWA, T ;

MARUYAMA, S ;

KAWAICHI, M ;

HONJO, T .

CELL, 1992, 69 (07) :1191-1197

[9] A NOVEL REPRESSION MODULE, AN EXTENSIVE ACTIVATION DOMAIN, AND A BIPARTITE NUCLEAR-LOCALIZATION SIGNAL DEFINED IN THE IMMEDIATE-EARLY TRANSCRIPTION FACTOR EGR-1 [J].

GASHLER, AL ;

SWAMINATHAN, S ;

SUKHATME, VP .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :4556-4571

[10] THE EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 TRANSACTIVATOR IS DIRECTED TO RESPONSE ELEMENTS BY THE J-KAPPA RECOMBINATION SIGNAL BINDING-PROTEIN [J].

GROSSMAN, SR ;

JOHANNSEN, E ;

TONG, X ;

YALAMANCHILI, R ;

KIEFF, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7568-7572