A CONVENIENT METHOD FOR CYANATION OF AROMATIC IODO COMPOUNDS

被引：21

作者：

CARR, RM

CABLE, KM

WELLS, GN

SUTHERLAND, DR

机构：

[1] Isotope Chemistry Group, Chemical Development Division, Glaxo Research and Development Limited, Greenford, Middlesex

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 09期

关键词：

CYANATION; ARYL IODIDES; C-13; C-14;

D O I：

10.1002/jlcr.2580340910

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A variety of [C-13]-labelled aromatic nitriles have been prepared in good yield from iodoaromatic substrates. Cyanation was achieved by reaction of aryl iodides with a mixture of potassium [C-13]cyanide and copper (I) iodide in an aprotic solvent at high temperature. The use of pre-prepared carbon-labelled copper (I) cyanide was therefore obviated.

引用

页码：887 / 897

页数：11

共 14 条

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