IN-VITRO ACTIVITY OF ROKITAMYCIN, A NEW MACROLIDE, AGAINST BORRELIA-BURGDORFERI

被引:6
作者
CINCO, M [1 ]
PADOVAN, D [1 ]
STINCO, G [1 ]
TREVISAN, G [1 ]
机构
[1] UNIV TRIESTE, DEPT DERMATOL, I-34127 TRIESTE, ITALY
关键词
D O I
10.1128/AAC.39.5.1185
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The activity of rokitamycin, a new macrolide with a 16-member ring, was tested against Borrelia burgdorferi in vitro. The antibiotic had a lower MIC at which 50% of the isolates are inhibited than erythromycin, the parent 14-member macrolide, but the same MIC at which 50% of the isolates are inhibited as the other recent 14- and 15-member macrolides, like clarithromycin and azithromycin. The MBC was equal to the MIC at which 50% of the isolates are inhibited, so rokitamycin can be considered bactericidal against B. burgdorferi. The sensitivity of the Borrelia strains tested was not correlated with the particular species Burgdorferi sensu stricto,B. garinii, and B. afzelii or with the number of subcultures of the isolates.
引用
收藏
页码:1185 / 1186
页数:2
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